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Cake day: July 29th, 2023

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  • My parents’ generation, in the 1970s way dug anchovies on pizza which I found way too salty. I didn’t get it then, but I don’t see much in the way of anchovies on pizza now. So collective tastes may change with time.

    That makes me kinda sad. I’m definitely nowhere near that generation but I love anchovies on pizza, and people not ordering anchovies on pizza just makes it harder to find places that still offer anchovies. I think it’s the best pizza topping. Although I also don’t mind Hawaiian style pizza separately either.














  • I mostly agree with you, but it’s not like overdoses caused by medical errors don’t ever happen either. Because it has a longer half-life (due to biological women commonly having a higher percentage of body fat compared to biological men, for example), medication levels can build up (as you mentioned) and result in adverse effects if you make a mistake with dosing. Pharmacokinetics and pharmacodynamics do matter too.

    Just because it’s not common (because physicians are trained to handle it appropriately) doesn’t mean it’s not possible.

    Like you said, demographics (including age, biological sex, etc) do matter.



  • Cisgender women have a naturally higher percentage of body fat than cisgender men, so lipophilic drugs have a larger volume of distribution in women. They sink into the fat tissue, stay in the body longer, and can take much more time to clear out. Overlooking sex-based variations in volume of distribution can be dangerous in an emergency situation, it absolutely can result in adverse drug reactions.

    That kind of information can be a factor in an emergency medicine situation, it’s not worth pretending that it’s not the case.

    Medicine is one of the areas where biological sex is actually relevant.