Warning: Grapefruit can interact with drugs, such as decreasing the effectiveness of estradiol, making Oxycodone last longer, increasing blood levels when on Viagra, and much more.
Grapefruit inhibits multiple enzymes in the small intestine, most notably CYP3A4. CYP3A4 is involved in the breaking down of a lot of drugs, so when it’s inhibited Oxycodone becomes inactive slower, and estradiol won’t break down all the way into estrogen. Drugs that are affected by grapefruit will often have warnings on their packaging
Personally, I like putting just a little bit of salt on my grapefruit, to counteract the bitter flavor. Dumping sugar on it doesn’t help. Grapefruits are about half as sour as lemons, since they have half the citric acid content.
Grapefruits were accidentally created as a cross between the sweet orange and the pomelo, in Barbados. Those fruits originate from Asia, but were brought to the Caribbean in the 17th century. Since it’s parent fruits are native to Asia, it grows well in Asia too.
and 
(China and Vietnam) are the two largest producers of Grapefruits, producing collectively 6.3 million tons out of the 9.8 million tons of worldwide production.
The painting was made by Robert Papp, who has a website here: https://robertpapp.com/. I don’t really know anything about the guy.
The lemon things with all of the recipes was really cool, but to be honest I just like grapefruit raw, cut in half and ate with a spoon.
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Anyone here have experience with pioglitazone? Is sourcing discussion allowed here?
I mean there’s always this source if you’re feeling brave.
Not only is it allowed we have guides!
I don’t know if you can get glitazones through DIY source, I’m not sure how wise it is to self dose them without medical supervision. Are you using it to lose weight?
Not Babs, but I think there’s some decent speculation that the “weight loss” associated diabetic medications like glitazones, SGLT-2 inhibitors and GLP1 agonists (of ozempic fame) might have a very useful role in gender affirming medical care, in particularly in trans femmes, because of speeding up fat redistribution, basically giving faster and more dramatic results for HRT.
It one of those complicated things where yeah the science lags behind, because medicine and endocrinologists mostly don’t care about trans people, and trans people have to take it into their own hands, but also avoiding fueling disordered eating and anti-fatness.
Yeah it’s this. I’ve been on hrt like 16 years now but still have pretty unfortunate fat placement with a belly and very little butt. I never really weight cycled, but if I’m gonna put in that much effort to lose and gain weight I would like to make sure it goes to appropriate places. I have seen much talk of pioglitazone for this purpose and was curious if anyone had experience or if I get to be a guinea pig.
But also, it doesn’t pop up in most hrt sources and the pharmacies I’ve used in the past don’t seem to stock it.
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